Nesekem, the Herald
Nearby enemies are randomly marked every 5 seconds. Marked enemies will be inflicted with Vulnerable, and all attacks made against them are guaranteed critical hits and Overpower. Hitting the same marked target 10 times removes the mark from them. This weapon is exclusive to the Spiritborn class.
Ahavarion, Spear of Lycander
Killing an Elite enemy grants you a random Shirine effect that lasts 20 seconds. This effect has a 30-second cooldown. Exclusive to the Necromancer and Druid class.
Shattered Vow
Enemies inflicted with a damage over time effect that is more than their remaining health are instantly executed. Only the Barbarian, Druid, and Spiritborn classes can use this weapon.
The Grandfather
Increases Critical Strike damage by 100%. All the implicit affix values can roll higher than their cap. Can only be used by Barbarians and Necromancers.
Besides the ones above, there are also some classic Uber Unqiues that are class-agnostic, meaning all classes can use them. Those are:
Harlequin Crest
Receive 20% damage reduction and +4 ranks to all Skills.
Andariel’s Visage
Proccing a Lucky Hit has a 20% chance of unleashing a Poison Nova that deals 4500 Poison damage over 5 seconds.
Doombringer
On a Lucky Hit, it has a 20% chance to unleash a burst of Shadow damage that reduces the damage of nearby enemies by 20%
Heir of Perdition
Wearing this helmet grants you Mother’s Favor, which is a 60% damage buff. While wearing Heir of Perdition, you can steal the buff of nearby allies wearing the helmet by killing enemies.
Ring of Starless Skies
Expending your class’s Primary Resource reduces the resource cost of all Skills and increases your damage output by 10%, which can stack to a maximum of 50%
Melted Heart of Sellig
You gain 60 Maximum Resource. When taking damage, 75% of the damage you receive is instead drained as 2 Resource for every 1% health that would have been lost.
Tyrael’s Might
While you have full health, all your skills will also unleash a divine barrage that deals damage.
Shroud of False Death
Gain Stealth and 40% extra movement speed if you have not made an attack in 2 seconds.